Five types of stability generally recognized are shown in the accompanying table.Each ingredient, whether therapeutically active or pharmaceutically necessary, can affect the stability of drug substances and dosage forms.In dosage forms, the following reactions usually cause loss of active drug content, and they usually do not provide obvious visual or olfactory evidence of their occurrence.Esters and -lactams are the chemical bonds that are most likely to hydrolyze in the presence of water.Most consumers mistakenly believe that expiration dates on food indicate how safe the food is to consume, when these dates actually are NOT related to the risk of food poisoning or food-borne illness.The dates solely indicate in the sense of becoming inedible.After cutting, wash and dry each specimen, taking care to avoid scratching the surfaces.If the specimen is too small to cover the opening in the specimen holder, mask the uncovered portion of the opening with opaque paper or masking tape, provided that the length of the specimen is greater than that of the slit in the spectrophotometer.
The stability and clinical effect of manufactured dosage forms can be greatly compromised by seemingly negligible alterations or inappropriate prescription compounding.
For transparent glass or plastic pharmaceutical containers, use a spectrophotometer of suitable sensitivity and accuracy for measuring and recording the amount of light transmitted.
For translucent glass or plastic pharmaceutical containers, use a spectrophotometer as described above that, in addition, is capable of measuring and recording light transmitted in diffused as well as parallel rays.
Use-by dates are contributing to millions of pounds of wasted food each year.
A report from the Natural Resources Defense Council and Harvard Law School’s Food Law and Policy Clinic says Americans are prematurely throwing out food, largely because of confusion over what expiration dates actually mean.